Iranian Supreme Leader Ali Khamenei has publicly dismissed any prospective agreement with the Trump administration as 'worthless,' vowing a forceful Iranian response as fighting continues across the region. The declaration marks a significant hardening of Tehran's posture amid active hostilities that have drawn in neighboring countries.

Kuwait reported attacks in connection with the ongoing conflict, according to live updates tracking the rapidly evolving situation. The spread of incidents beyond Iran's immediate borders has raised concerns among regional governments and international observers about further escalation.

The U.S. State Department responded by issuing a worldwide caution advisory, urging American citizens to exercise heightened vigilance when traveling internationally, with particular emphasis on the Middle East. The advisory reflects Washington's assessment that the risk of retaliatory or spillover violence has grown substantially.

Amid the turmoil, American citizen Dena Karari arrived back in the United States after being wrongfully detained by Iran for 566 days on spying charges. Her return comes as diplomatic channels between Washington and Tehran remain severely strained, with Khamenei's public rejection of any deal underscoring the depth of the impasse.

The combination of Khamenei's statement, continued regional attacks, and the State Department advisory signals a period of heightened tension with few immediate diplomatic off-ramps visible. Analysts note that public declarations of this nature from Iran's supreme leader typically constrain the flexibility of Iranian negotiators and harden factional positions within the country's government.